On this day in economic and business history...
Merck (NYSE: MRK ) took its first steps toward pharmaceutical dominance on April 30, 1953, when it merged with Sharp & Dohme, a pharmaceutical manufacturer. Until that time, Merck had been primarily a chemical manufacturer, despite its role in producing the earliest doses of penicillin. Together, the two companies combined for $156 million in sales and $12 million in net income for the 1952 fiscal year, but the new Merck's growth was just beginning -- as was its role in modern pharmaceuticals.
Four years after the merger, Maurice Hilleman joined Merck as its head of virus and cell biology research. In this role, Hilleman would develop so many life-saving vaccines that he was later called "the most successful vaccinologist in history" and was credited with potentially saving more lives than any other scientist of the 20th century. Two of Hilleman's critical vaccine developments while at Merck included one for mumps (now part of the standard MMR vaccine) and one for hepatitis B, the latter of which has reduced the disease's incidence in American children by more than 95%.
Best Warren Buffett Companies To Watch For 2016: MDU Resources Group Inc (MRE)
MDU Resources Group, Inc.,incorporated on March 14, 1924, is a diversified natural resource company. Montana-Dakota Utilities Co. (Montana-Dakota) is a public utility division of the Company. Montana-Dakota, through the electric and natural gas distribution segments, generates, transmits and distributes electricity and distributes natural gas in Montana, North Dakota, South Dakota and Wyoming. Cascade Natural Gas Corporation (Cascade), which is an indirect wholly owned subsidiary of MDU Energy Capital, distributes natural gas in Oregon and Washington. Intermountain Gas Company (Intermountain) distributes natural gas in Idaho. Great Plains Natural Gas Co. (Great Plains), which is a public utility division of the Company, distributes natural gas in western Minnesota and southeastern North Dakota. These operations also supply related value-added services. The Company��s segments include electric, pipeline and energy services, exploration and production, construction materials and contracting and construction services.
The Company, through its wholly owned subsidiary, Centennial Energy Holdings, Inc. (Centennial), owns WBI Holdings, Inc. (WBI Holdings) (consisting of the pipeline and energy services and the exploration and production segments), Knife River Corporation (Knife River) (construction materials and contracting segment), MDU Construction Services Group, Inc. (MDU Construction Services) (construction services segment), Centennial Energy Resources LLC (Centennial Resources) and Centennial Holdings Capital LLC (Centennial Capital) (both included in the Other category). The Company produces Greenhouse gas (GHG) emissions primarily from its fossil fuel electric generating facilities, as well as from natural gas pipeline and storage systems, operations of equipment and fleet vehicles, and oil and natural gas exploration and development activities.
Electric
Montana-Dakota provides electric service at retail, serving more than 131,000 residential, commercial, indu! strial and municipal customers in 177 communities and adjacent rural areas as of December 31, 2012. The principal properties owned by Montana-Dakota for use in its electric operations include interests in 10 electric generating facilities and three small portable diesel generators, as further described under System Supply, System Demand and Competition, approximately 3,100 and 4,700 miles of transmission and distribution lines, respectively and 51 transmission and 268 distribution substations. Montana-Dakota has obtained and holds valid and existing franchises authorizing it to conduct its electric operations in all of the municipalities it serves where such franchises are required.
The Company, through the Midwest Independent Transmission System Operator, Inc. (Midwest ISO), Montana-Dakota has access to wholesale energy, ancillary services and capacity markets. The Midwest ISO is a regional transmission organization responsible for operational control of the transmission systems of its members. The Midwest ISO provides security center operations, tariff administration and operates day-ahead and real-time energy markets, ancillary services and capacity markets. In 2012, Montana-Dakota purchased approximately 27 % of its net kilowatts-hour needs for its interconnected system through the Midwest ISO market.
Montana-Dakota serves markets in portions of western North Dakota, including Bismarck, Mandan, Dickinson and Williston; eastern Montana, including Glendive and Miles City; and northern South Dakota, including Mobridge. The maximum electric peak demand experienced to date attributable to Montana-Dakota's sales to retail customers on the interconnected system was 573,587 kilowatts in July, 2012. The interconnected system consists of nine electric generating facilities and three small portable diesel generators, which has an aggregate nameplate rating attributable to Montana-Dakota's interest of 488,905 kilowatts. Through the Sheridan System, which is a separate electric system o! wned by M! ontana-Dakota, Montana-Dakota serves Sheridan, Wyoming, and neighboring communities. The maximum peak demand attributable to Montana-Dakota sales to retail customers on that system was approximately 61,501 kilowatts in July, 2012.
Montana-Dakota's four principal generating stations are steam-turbine generating units, which uses coal for fuel. The nameplate rating for Montana-Dakota's ownership interest in these four stations , including interests in the Big Stone Station and the Coyote Station, aggregating 22.7 % and 25%, respectively is 327,758 kilowatts. Two combustion turbine peaking stations, two wind electric generating facilities, a heat recovery electric generating facility and three small portable diesel generators supply the balance of Montana-Dakota's interconnected system electric generating capability.
The Coyote coal supply agreement provides for the purchase of coal necessary to supply the coal requirements of the Coyote Station or 30,000 tons per week, whichever may be the greater quantity at contracted pricing. The Heskett and Lewis & Clark coal supply agreements provide for the purchase of coal necessary to supply the coal requirements of these stations at contracted pricing. Montana-Dakota estimates the Heskett and Lewis & Clark coal requirement to be in the range of 450,000 to 550,000 tons and 250,000 to 350,000 tons per contract year, respectively
Natural Gas Distribution
The Company's natural gas distribution operations consist of Montana-Dakota, Great Plains, Cascade and Intermountain, which sell natural gas at retail, serving over 859,000 residential, commercial and industrial customers in 334 communities and adjacent rural areas across eight states as of December 31, 2012, and provide natural gas transportation services to certain customers on their systems. These services are provided through distribution systems aggregating approximately 18,200 miles.
The Company's purchased natural gas is supplied by a po! rtfolio o! f contracts specifying market-based pricing and is transported under transportation agreements with WBI Energy Transmission, Northwest Pipeline GP, Northern Natural Gas, Gas Transmission Northwest LLC, Northwestern Energy, Viking Gas Transmission Company and Ruby Pipeline LLC. The natural gas distribution operations have contracts for storage services to provide gas supply during the winter heating season and to meet peak day demand with various storage providers, including WBI Energy Transmission, Questar Pipeline Company, Northwest Pipeline GP and Northern Natural Gas. In addition, certain of the operations have entered into natural gas supply management agreements with various parties.
Pipeline and Energy Services
WBI Energy Transmission, the regulated business of this segment, owns and operates approximately 3,800 miles of transmission, gathering and storage lines in Montana, North Dakota, South Dakota and Wyoming. WBI Energy Midstream owns a 50% undivided interest in certain midstream assets located in western North Dakota. Three underground storage fields in Montana and Wyoming provide storage services to local distribution companies, producers, natural gas marketers and others, and serve to enhance system deliverability. WBI Energy Transmission's system is located near five natural gas producing basins, making natural gas supplies available to WBI Energy Transmission's transportation and storage customers. The system has 13 interconnecting points with other pipeline facilities allowing for the receipt and/or delivery of natural gas to and from other regions of the country and from Canada.
WBI Energy Midstream, the non-regulated pipeline business of this segment, owns and operates gathering facilities in Colorado, Kansas, Montana and Wyoming. It also owns a 50% undivided interest in certain midstream assets located in western North Dakota that were acquired in 2012, which include a natural gas processing plant, both oil and gas gathering pipelines, an ! oil stora! ge terminal and an oil pipeline. Prairielands is an energy services business,which provides natural gas purchase and sales services to local distribution companies, producers, other marketers and a limited number of end-users, primarily using natural gas produced by the Company's exploration and production segment. WBI Energy Transmission's underground natural gas storage facilities has a storage capacity of approximately 353 billion cubic feet, including 193 billion cubic feet of working gas capacity, 85 billion cubic feet of cushion gas and 75 billion cubic feet of native gas.
Exploration and Production
Fidelity is involved in the acquisition, exploration, development and production of oil and natural gas resources. Fidelity continues to seek additional reserve and production growth opportunities through these activities. Fidelity's business is focused primarily in two core regions: Rocky Mountain and Mid-Continent/Gulf States.
Fidelity's Rocky Mountain region includes Bakken areas , which includes oil targets in which Fidelity holds approximately 16,000 net acres in Mountrail County, North Dakota, approximately 51,000 net acres in Stark County, North Dakota, and approximately 60,000 net acres in Richland County, Montana; Cedar Creek Anticline, which is in primarily in eastern Montana, the Company has a long-held net profits interest in this oil play. Paradox Basin holds approximately 83,000 net acres located in Grand and San Juan Counties, Utah, targeting oil; Big Horn Basin includes approximately 33,000 net acres in Wyoming, targeting oil and Natural gas liquids (NGL); Green River Basin properties primarily includes natural gas targets in Wyoming in which the Company holds approximately 36,000 net acres; Baker Field is a long-held natural gas properties in which Fidelity holds approximately 99,000 net acres in southeastern Montana and southwestern North Dakota; Bowdoin Field is a long-held natural gas properties in which Fidelity holds approximately 127,000 net! acres in! north-central Montana, and Other includes other exploratory oil projects in the Niobrara play in Wyoming and the Heath Shale in Montana; along with the Powder River Basin natural gas properties, which Fidelity is pursuing divestment of and various non-operated positions.
Fidelity's Mid-Continent/Gulf States region includes South Texas area includes approximately 9,000 net acres in the Tabasco, Texan Gardens and Flores fields, this area has NGL content associated with the natural gas. East/Central Texas holds approximately 27,000 net acres, primarily natural gas and associated NGL. Other includes various non-operated onshore interests, as well as offshore interests in the shallow waters off the coasts of Texas and Louisiana. At December 31, 2012, there were 44 gross (17 net) wells in the process of drilling or under evaluation, 39 of which were development wells and 5 of which were exploratory wells.
Construction Materials and Contracting
Knife River operates construction materials and contracting businesses. These operations mine, process and sell construction aggregates (crushed stone, sand and gravel); produce and sell asphalt mix and supply ready-mixed concrete for construction, including roads, freeways and bridges, as well as homes, schools, shopping centers, office buildings and industrial parks. Although not common to all locations, other products include the sale of cement, liquid asphalt for various commercial and roadway applications, various finished concrete products and other building materials and related contracting services.
Construction Services
MDU Construction Services specializes in constructing and maintaining electric and communication lines, gas pipelines, fire suppression systems, and external lighting and traffic signalization equipment. This segment also provides utility excavation services and inside electrical wiring, cabling and mechanical services, sells and distributes electrical materials, and manufactures ! and distr! ibutes specialty equipment. These services are provided to utilities and manufacturing, commercial, industrial, institutional and government customers. MDU Construction Services operates a fleet of owned and leased trucks and trailers, support vehicles and specialty construction equipment, such as backhoes, excavators, trenchers, generators, boring machines and cranes. In addition, as of December 31, 2012, MDU Construction Services owned or leased facilities in 17 states. This space is used for offices, equipment yards, warehousing, storage and vehicle shops.
Advisors' Opinion:- [By Eric Lam]
Martinrea International Inc. (MRE), a metal auto-parts maker, slumped 10 percent to C$10.96 after the company said it received a press release discussing a claim from Nat Rea, former vice chairman of the company. Martinrea has not received the claim or reviewed the allegations and will ��respond appropriately in due course.��
Top Income Stocks To Watch For 2015: Pruksa Real Estate PCL (PS)
Pruksa Real Estate PCL is a Thailand-based company engaged in the development of commercial buildings and residential housing. It serves both local and overseas markets. The Company offers single-detached houses, townhouses and condominiums under the names of Baan Pruksa, Pruksa Ville, The Connect, The Plant Citi, Passorn, Pruksa Village, The Seed, IVY, The Plant City, Urbano, Tree condo, ChapterOne and Be You, among others. The Company develops residential housing projects mainly in Bangkok and the surrounding areas. It also has projects in Nakhorn Pathom, Chonburi and Phuket, as well as overseas projects in India, Vietnam, and Maldives. As of December 31, 2012, it operated 141 projects and had five direct subsidiaries, including Kaysorn Construction Company Limited, Putthachart Estate Company Limited, Phanalee Estate Company Limited, Pruksa Overseas Company Limited and Pruksa International Company Limited. Advisors' Opinion:- [By amigobulls@twitter]
Twitter currently trades at a Last Twelve Months (LTM) Price to Sales (PS) ratio of 27, which translates to astronomical valuations. Consider a comparison with Facebook which generates about 10 times the revenue and still grows at a healthy 60 odd percent. Facebook trades at an LTM PS multiple of 19. Here one should note that Facebook also delivered a net profit margin of 27% in Q2 vs Twitter's loss margin of 46% and has nearly 5 times Twitter's active users.
Top Income Stocks To Watch For 2015: Elan Corporation PLC (ELN)
Elan Corporation, plc (Elan), incorporated in December 1969, is a neuroscience-based biotechnology company. The Company is focused on discovering and developing advanced therapies in neurodegenerative and autoimmune diseases. Elan��s business focuses on neurodegenerative diseases, such as Alzheimer��s disease and Parkinson��s disease; autoimmune diseases, including MS and Crohn��s disease and neo-epitope based targets for treatments across a range of therapeutic indications. Tysabri is a treatment for MS and Crohn��s disease that the Company markets and distributes with Biogen Idec. On September 16, 2011, Elan sold its EDT business to Alkermes, Inc. In November 2011, Elan launched a collaboration with the University of Cambridge, England, the Cambridge-Elan Centre for Research Innovation and Drug Discovery (Cambridge-Elan Centre). On December 21, 2012, the Company completed the demerger of Prothena Corporation plc. In April 2013, it closed the TYSABRI (natalizumab) Collaboration Transaction with Biogen Idec.
Tysabri
Tysabri, which is an alpha-4 integrin inhibitor, is a therapy for MS, a neurological disorder involving central nervous system dysfunction among adults. Tysabri is approved in more than 65 countries. Tysabri is approved in the United States as a monotherapy for relapsing forms of MS, for patients who have had an inadequate response to, or are unable to tolerate, an alternative MS therapy. In the European Union, it is approved for relapsing-remitting MS (RRMS) in adult patients who have failed to respond to beta interferon or have rapidly evolving, severe RRMS. As of December 31, 2011, there were approximately 64,400 patients on Tysabri therapy worldwide.
In June 2011, the European Commission (EC) approved the inclusion of the anti-JCV antibody status as an additional factor in stratifying patients at risk for developing PML in the Summary of Product Characteristics�� (SmPC) for Tysabri in the European Union. The Company has developed a two-step ! enzyme-linked immunosorbent assay (ELISA), STRATIFY JCV, with Biogen Idec. The assay detects anti-JCV antibodies in the blood of patients, and is commercially available in Europe. In January 2012, the FDA cleared the assay for commercial use in the United States. As of December 31, 2011, over 80,000 tests had been administered using the assay. Tysabri is marketed and distributed by Elan and Biogen Idec. The Company��s research group, Neotope, is focused on creating monoclonal antibodies based on neo-epitope targets for the treatment of a range of therapeutic indications.
Beta Amyloid Immunotherapies (AIP)
Beta amyloid immunotherapy includes the treatment of Alzheimer��s disease by inducing or enhancing the body��s immune response in order to clear toxic species of beta amyloid from the brain. The AIP includes bapineuzumab (intravenous and subcutaneous delivery) and ACC-001, as well as other compounds. Bapineuzumab is an experimental humanized monoclonal antibody delivered intravenously that is being studied as a treatment for mild to moderate Alzheimer��s disease. It is designed to provide antibodies to beta amyloid directly to the patient (passive immunotherapy).
ELND005, an A� Aggregation Inhibitor
The small molecule ELND005 (Scyllo-inositol) is a beta amyloid anti-aggregation agent. Preclinical data suggest that ELND005 may act through the mechanism of preventing and reversing the fibrilisation of beta amyloid (the aggregation of beta amyloid into clumps of insoluble oligomers). ELND005 may have additional applications in psychiatric indications, such as bipolar disorder. In November 2011, the Company entered into a manufacturing agreement for the supply of the active pharmaceutical ingredient for ELND005 with Lonza Group AG.
Neotope Biosciences Limited
Neotope Biosciences Limited (Neotope) is the Company��s wholly owned subsidiary that focuses on the discovery and development of antibodies to neo-epitope related targ! ets for t! he treatment of a range of indications. It includes amyloidosis, diabetes, cancer and macular degeneration. Neotope��s portfolio of targets includes alpha-synuclein for the potential treatment of synucleinopathies, such as Lewy body dementia and Parkinson��s disease, tau for Alzheimer��s disease and other tauopathies. It also has a program for type 2-diabetes.
Onclave Therapeutics Limited
Elan��s wholly owned subsidiary Onclave Therapeutics Limited (Onclave) was formed to develop assets originating from Elan that have application in oncology related diseases. Onclave��s program, NEOD001, which originated from Neotope, is being investigated for the treatment of AL amyloidosis, which is a fatal disease involving abnormal accumulation of amyloid in organs and tissue. During the year ended December 31, 2011, Onclave filed for orphan drug designation of NEOD001. Onclave��s pipeline includes additional compounds with relevance in diverse cancer indications.
The Company competes with Biogen Idec, Bayer Schering Pharma AG, Bayer Schering Pharma, Merck Serono, Pfizer, Teva Neurosciences, Inc., Sanofi-Aventis and Novartis AG.
Advisors' Opinion:- [By Sofia Horta e Costa]
Bellway Plc (BWY) added 1.4 percent after the homebuilder said reservations in the past four months rose 31 percent as buyers had greater access to mortgages. Elan (ELN) Corp. jumped to a 10-month high in Dublin after Royalty Pharma increased its offer for the Irish drugmaker to as much as $6.7 billion. BT Group increased 3.7 percent as Barclays Plc recommended investors buy shares of the U.K.��s largest fixed-line company.
- [By Brian Orelli]
Up for sale
After Elan (NYSE: ELN ) failed to convince its shareholders that its new business model was the right one, the biotech company formally put itself up for sale last Friday. - [By Russ Krull]
Finally, Ireland-based biotech Elan (NYSE: ELN ) issued $850 million of eight-year notes. The money is going to help pay for a royalty stake in some Theravance products. Elan expects the transaction to add to earnings starting in 2014. My Foolish colleagues Sean Williams and Brian Orelli think this might be a better deal for Theravance than for Elan.
- [By Brian Orelli]
Most recently Elan (NYSE: ELN ) spun out its drug discovery business into Prothena. Without the burden of a drug discovery unit, the parent company is now being pursued by Royalty Pharma, although Elan isn't keen on its current offer.
Top Income Stocks To Watch For 2015: (AUQ)
AuRico Gold Inc. engages in the exploration, development, and production of gold and silver projects and properties in Canada, Mexico, and Australia. Its principal property includes the Ocampo mine covering approximately 15,000 hectares located in Chihuahua State. The company was formerly known as Gammon Gold Inc. and changed its name to AuRico Gold Inc. in June 2011. AuRico Gold Inc. was founded in 1986 and is based in Toronto, Canada.
Advisors' Opinion:- [By Garrett Cook]
Basic materials sector was the top loser in the US market on Tuesday. Top decliners in the sector included Kraton Performance Polymers (NYSE: KRA), Molycorp (NYSE: MCP), and AuRico Gold (NYSE: AUQ).
- [By GuruFocus]
George Soros (Trades, Portfolio) just reported his first quarter portfolio. He buys Citrix Systems Inc, Baker Hughes Inc, Comcast Corp, Spansion Inc, etc during the 3-months ended 03/31/2014, according to the most recent filings of his investment company, Soros Fund Management LLC. As of 03/31/2014, Soros Fund Management LLC owns 305 stocks with a total value of $10.1 billion. These are the details of the buys and sells.New Purchases: BHI, CODE, CTRP, CLI, AVB, COMM, CNQ, AGO, AUY, ATML, ASH, BXMT, CSTM, AEM, CMA, ARE, CHKP, AUQ, BEAV, CX, ADSK, AALCP, BLK, AIG, BIIB, ADEP, AMRI, ARWR, ATHX, BALT, BCRX, BEAT, CFX, CLFD, CUR, CODE,Added Positions: CTXS, CMCSA, CNP, ALTR, BRCD, CBS, CRM, CHTR, CCJ, CIEN, BIDU, ALLE, ABT, CDNS, ACT,Reduced Positions: AAPL, CCI, AMT, ABBV, AAL, BITA, AL, ANGI, ARIA, CBST, BA, BIRT, EXAR,Sold Out: C, BAC, CRI, AMZN, AGN, CF, BRCM, COTY, BMY, AMCX, CAR, A, ADBE, AFL,For the details of George Soros (Trades, Portfolio)'s stock buys and sells, go to http://www.gurufocus.com/StockBuy.php?GuruName=George+SorosThis is the sector weightings of his portfolio:Technology18.9%Energy14%Healthcare8.3%Consumer Defensive8.2%Communication Services8.1%Consumer Cyclical5.4%Industrials5.1%Basic Materials4.9%Financial Services2.5%Real Estate1.9%Utilities0.5%These are the top 5 holdings of George Soros (Trades, Portfolio)1. Teva Pharmaceutical Industries Ltd (TEVA) - 10,310,041 shares, 5.4% of the total portfolio. Shares added by 10.67%2. Herbalife Ltd (HLF) - 4,901,337 shares, 2.8% of the total portfolio. Shares added by 52.9%3. EQT Corp (EQT) - 2,573,814 shares, 2.5% of the total portfolio. Shares added by 3.27%4. Adecoagro SA (AGRO) - 25,915,076 shares, 2.1% of the total portfolio.5. Halliburton Co (HAL) - 3,596,353 shares, 2.1% of the total portfolio. Shares reduced by 20.73%New Purchase: Baker Hughes Inc (BHI)George Soros (Trades, Portfolio) initiated holdings in Baker Hughes Inc. His purchase prices were between $51.82 and $65.27, with an estimated
- [By Garrett Cook]
Basic materials sector was the top loser in the US market on Tuesday. Top decliners in the sector included Kraton Performance Polymers (NYSE: KRA), Molycorp (NYSE: MCP), and AuRico Gold (NYSE: AUQ).
- [By Sean Williams]
Then there's the company's El Cubo mine, which it purchased in 2012 from AuRico Gold (NYSE: AUQ ) with a combination of its own shares and cash for up to $250 million ($50 million is contingent on mine productivity over a three-year period). As fellow Fool Christopher Barker has commented previously, AuRico did a disastrous job of managing the El Cubo mine, which leaves Endeavour with a tremendous opportunity to reap the rewards of AuRico's failures.
