Investors were reacting to mixed first-quarter earnings reports and continued jitters over Ukraine.
The Dow Jones industrial average was down 0.2% to 16,513 and the Standard & Poor's 500 index dropped 0.4% to 1,868.
The Nasdaq fell 0.6% to 4,028. The tech-heavy index has dropped 77 points in the past three days.
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The yield on the 10-year Treasury note fell slightly to 2.61%, down from 2.62% Thursday.
European shares were lower amid renewed jitters about Ukraine. Pro-Russian militants are pressing ahead with plans for an independence referendum.
Britain's FTSE 100 and Germany's DAX were both down 0.4%. France's CAC-40 dropped 0.7%. I
In Asia, the Nikkei advanced in choppy trade. The index ended 0.3% higher at 14,199.59. In notable economic news out of China, inflation there eased in April to 1.8%.
Thursday, the Dow rose 32.43 points, or 0.2%, to 16,550.97 and S&P 500 index fell 2.58 points, or 0.1%, to 1,875.63. The Nasdaq fell 16.17 points, or 0.4%, to 4,051.50.
Contributing: The Associated Press
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