Yesterday, Merck (NYSE: MRK ) reported overwhelmingly positive interim results for its experimental melanoma drug lambrolizumab. This antibody, which belongs to an emerging class of cancer therapeutics called PD-1 drugs, was tested in a phase 1B clinical study with a total of 135 patients at three different doses. A 38% response rate was reported across the three cohorts, and patients on a bi-monthly regimen of lambrolizumab at the highest dose (10 milligrams per kilogram) displayed a 52% response rate. The interim results were reported in detail at the American Society of Clinical Oncology�and in the New England Journal of Medicine.
Fight against melanoma
According to the American Cancer Society, the rate of melanoma diagnoses have grown over the last three decades, and more than 76,000 people will be diagnosed this year. Last week, the FDA approved two GlaxoSmithKline drugs -- Tafinlar and Mekinist -- for the treatment of advanced melanoma. However, the spotlight has recently shifted to PD-1 drugs in development at Merck, Bristol-Myers Squibb� (NYSE: BMY ) , and Roche.
Hot Stocks To Buy Right Now: VisionChina Media Inc.(VISN)
VisionChina Media Inc., through its subsidiaries, provides advertising services in the People?s Republic of China. The company operates out-of-home advertising network using real-time mobile digital television broadcasts to deliver content and advertising on mass transportation systems. Its mobile digital television advertising network delivers real-time content provided by the local television stations. The company?s network also displays real-time news and stock quotes, weather and traffic updates, sports highlights, and other programs, as well as disseminates public-interest messages and programs that promote the general welfare of society and other urgent messages during emergency situations, such as typhoons, earthquakes, and other events that concern public safety. Its advertising network consists of digital television displays primarily located on buses, and in subway trains and subway platforms that receive mobile digital television broadcasts of real-time conten t and advertising. The company also operates various closed-circuit advertising digital displays in subway platforms and subway trains in Beijing, Chongqing, Guangzhou, Nanjing, Shenzhen, and Tianjin, as well as in subway trains in Hong Kong. As of December 31, 2010, its network and supplemental subway advertising platform covered 23 cities in China and consisted of approximately 137,395 digital displays. The company sells its advertising time through direct sales force and third party advertising agencies. VisionChina Media Inc. was founded in 2005 and is headquartered in Shenzhen, the People?s Republic of China.
Advisors' Opinion:- [By Monica Gerson]
VisionChina Media (NASDAQ: VISN) surged 31.25% to $31.75 in the pre-market session after the company announced an exclusive strategic cooperation with Baidu Games.
Top 5 Forestry Companies For 2014: G-III Apparel Group Ltd (GIII)
G-III Apparel Group, Ltd. (G-III) designs, manufactures and markets a range of apparel, including outerwear, dresses, sportswear, women�� suits and women�� performance wear, as well as luggage and women�� handbags, small leather goods and cold weather accessories. It operates in three segments: wholesale licensed products, wholesale non-licensed products and retail operations. The wholesale licensed products segment includes sales of products under brands licensed by it from third parties. The wholesale non-licensed products segment includes sales of products under its own brands and private label brands. The retail operations segment consists almost entirely of the operations of its Wilsons outlet stores. The Company sells its products under its own brands, which include Andrew Marc, Marc New York and Marc Moto, licensed brands and private retail labels. In August 2012, the Company acquired Vilebrequin, a provider of swimwear, accessories and resort-wear. Effective November 4, 2013, G-III Apparel Group Ltd acquired GH Bass & Co.
The Company provides apparel under recognized brands to a cross section of retailers, such as Macy��, Bloomingdale��, Nordstrom, Lord & Taylor, The Bon-Ton Stores, Dillards, JC Penney, Belk and Kohl��. As of January 31, 2012, the Company operated 139 retail stores, of which 135 are outlet stores operated under the Wilsons Leather name and four are outlet stores operated under its Andrew Marc brand. It has licenses to produce branded fashion apparel under the Calvin Klein, Kenneth Cole, Cole Haan, Guess?, Tommy Hilfiger, Levi��, Dockers, Jessica Simpson, Ellen Tracy, Kensie, Mac & Jac, Jones New York, Sean John and Nine West brands, among others. It also has sports licenses with the National Football League, National Basketball Association, Major League Baseball, National Hockey League, Touch by Alyssa Milano and over 100 United States colleges and universities. G-III sells outerwear, dresses and handbags under the Company�� own Andrew Marc, Marc ! New York and Marc Moto brands and has licensed these brands to select third parties in certain product categories. Its other owned brands include, among others, Jessica Howard, Eliza J, Black Rivet, G-III, G-III Sports by Carl Banks and Winlit.
The Company works with a group of retailers, such as JC Penney, Kohl�� and Express in developing private label product lines. G-III�� products are sold primarily to department, specialty and mass merchant retail stores in the United States. It sells to approximately 2,400 customers, ranging from national and regional chains to small specialty stores. It also distributes its products through its retail outlet stores. It also markets its products in Canada, Europe and the Far East.
G-III�� branded apparel also consists of both women�� and men�� products. The Andrew Marc line of women�� and men�� luxury apparel is sold to upscale department and specialty retail stores. The Marc New York line of women�� and men�� better priced outerwear is sold to upper tier stores. The Marc Moto line is a men�� denim lifestyle collection of sportswear and accessories. The Jessica Howard label is a moderate price dress line that sells to department stores, specialty stores and catalogs. Eliza J is a better dress line that sells to better department and specialty stores. The Black Rivet line of apparel consists of women�� and men�� outerwear. It sells men�� sports-related apparel under its G-III Sports by Carl Banks label.
Advisors' Opinion:- [By Marshall Hargrave]
G-III Apparel Group (GIII) continues its trend of beating earnings estimates. Ok, ok, we're being modest, they've been crushing earnings. In the July ended quarter, GIII beat earnings consensus by 70%, and in the previous quarter, the company smashed earnings by 200%.
- [By Seth Jayson]
Basic guidelines
In this series, I examine inventory using a simple rule of thumb: Inventory increases ought to roughly parallel revenue increases. If inventory bloats more quickly than sales grow, this might be a sign that expected sales haven't materialized. Is the current inventory situation at G-III Apparel Group (Nasdaq: GIII ) out of line? To figure that out, start by comparing the company's inventory growth to sales growth. How is G-III Apparel Group doing by this quick checkup? At first glance, pretty well. Trailing-12-month revenue increased 14.2%, and inventory increased 16.0%. Comparing the latest quarter to the prior-year quarter, the story looks decent. Revenue expanded 18.8%, and inventory grew 16.0%. Over the sequential quarterly period, the trend looks worrisome. Revenue dropped 27.4%, and inventory dropped 13.8%.
Top 5 Forestry Companies For 2014: ProShares Ultra Dow30 (DDM)
ProShares Ultra Dow30 (the Fund) seeks daily investment results that correspond to twice (200%) the daily performance of the Dow Jones Industrial Average (DJIA). The DJIA is a price-weighted index maintained by editors of The Wall Street Journal. The Index includes 30 large-cap, blue-chip United States stocks, excluding utility and transportation companies. Components are selected through a discretionary process with no predetermined criteria except that components should be established United States companies. The DJIA is not limited to traditionally defined industrial stocks, instead, the Index serves as a measure of the entire United States market, covering such diverse industries as financial services, technology, retail, entertainment and consumer goods. The Fund takes positions in securities and/or financial instruments that, in combination, should have similar daily return characteristics as 200% of the daily return of the Index. Its investment advisor is ProShare Advisors LLC. Advisors' Opinion:- [By James Miller Phd]
In stock valuation models, dividend discount models (DDM) define cash flow as the dividends to be received by the shareholders. Extending the period indefinitely, the fundamental value of the stock is the present value of an infinite stream of dividends according to John Burr Williams.
- [By Victor Selva]
In stock valuation models, dividend discount models (DDM) define cash flow as the dividends to be received by the shareholders. Extending the period indefinitely, the fundamental value of the stock is the present value of an infinite stream of dividends according to John Burr Williams.
Top 5 Forestry Companies For 2014: OncoGenex Pharmaceuticals Inc.(OGXI)
OncoGenex Pharmaceuticals, Inc., a biopharmaceutical company, engages in the development and commercialization of new cancer therapies that address treatment resistance in cancer patients. The company?s clinical stage products include Custirsen, a phase III clinical stage product for treatment in men with metastatic castrate-resistant prostate cancer; OGX-427, which is in phase II clinical development stage is designed to inhibit heat shock protein 27; and SN2310 that completed phase I stage of clinical development is designed to evaluate safety in patients with advanced cancer. Its pre clinical stage products include GX-225 that is focused on reducing the production of IGFBP-2 and IGFBP-5; and CSP-9222, lead compound from a family of caspase activators. OncoGenex Pharmaceuticals, Inc. is based in Bothell, Washington.
Advisors' Opinion:- [By Lauren Pollock var popups = dojo.query(".socialByline .popC"); popups.forEach]
Teva Pharmaceutical Industries Ltd.(TEVA) and OncoGenex Pharmaceuticals Inc.(OGXI) said their experimental drug for hard-to-treat cases of prostate cancer didn’t result in statistically significant improvement in overall survival in a Phase 3 study. OncoGenex shares dropped 48% to $5 premarket.
- [By John McCamant]
2014 is shaping up to be the most important year for OncoGenex Pharmaceuticals (OGXI), and, we believe, it can very well represent a major inflection point for the company with positive Synergy results.
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